Comparative Analysis of microRNA Expression in Serum and Plasma in Patients Screened for BRCA1 or BRCA2 Mutations - dataset 3 part 1

This dataset consists of miRNA expression in plasma of 78 women with germline BRCA1/2 mutations and expression in serum of 11 of them. Serum samples of remaining 67 women have been already submitted to GEO in GSE226445 dataset and to SRA as Bioproject PRJNA898621, while counts generated in re-mapping for this project are deposited as GSE299846 data set. MicroRNA abundance was quantified with sequencing in both biological materials. Data was analyzed with the aim of assessing the impact of blood processing steps on quantified miRNA abundance. Generation of this dataset was supported by The Gray Foundation grant “Circulating microRNAs for assessment of risk beyond the BRCA genes and early detection of breast cancer in high-risk families” awarded to Dipanjan Chowdhury and Polish National Research Center grant OPUS “Predictive Potential of Circulating MicroRNA Biomarkers in Patients with High Familial or Genetic Risk of Cancer” (2023/49/B/NZ5/03835) awarded to Wojciech Fendler. Overall design: The experiment was performed in 78 pairs of human plasma and serum samples. All plasma samples belong to this submission, while in the case of serum 67 samples have been submitted previously, while the remaining 11 belong to this submission. All patients were female carriers of BRCA1/2 mutations, among them 1 had breast cancer at sample collection, 3 had ovarian cancer, 74 were healthy.