Monoclonal expansions dominate the islet-infiltrating CD4<sup>+</sup>CD44<sup>high</sup> T cell repertoire at diabetes onset<sup>1</sup>.
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1Monoclonal expansions are defined as clonotypes representing >15% of total CDR3β sequences. 2Numbers correspond to the diabetic mice identified in Table 1. Only the seven mice having monoclonal expansions are shown. 3Amino acid sequences between the conserved cysteine and phenylalanine residues, as defined by IMGT [57]. 4CDR3 length of nucleotides. 5Raw frequency of each clonotype within the total CDR3β sequences obtained from each mouse.
创建时间:
2013-10-17



