Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress

Experimental datasets for the results described in our paper "Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress", as reported in Nature Communications in 2025. Uploaded data include: solid-state NMR spectra SAXS results data files for multiple cellular and biochemical assays. See also the readme file, with contents as follows: The files are organized by type of data, and provided as ZIP archives for each data type. NMR data.zip ============ Batch 1 fibrils: Figure 4a Figure 4b SI Figure 6a SI Figure 6b Batch 2 fibrils: Figure 4c:SI Figure 9 (a) SI Figure 7(b) Figure 4d: SI Figure 9 (b) SI Figure 9c SI Figure 7(a) SI Figure 9d SAMPLE 5: SI Figure 10_CP SI Figure 10_INEPT TEM Images.zip ============== Figure 2 (c) Figure 2 (f) Figure 2 (i) Figure 2 (l) SI Figure 2 (e) Figure 2 (d) Figure 2 (g) Figure 2 (j) Figure 2(m) SI Figure 10 Figure 2 (e) Figure 2 (h) Figure 2 (k) SI Figure 2 (d) SAXS data.zip ============= Figure 2n-o Kinetics data.zip ================= Figure 2a: SI 2a SI Figure 1a:b SI fluorescence data Figure 2b: SI 2b SI Figure 1d Results from cellular assays ===================== Figure3c-d_images - folder with individual image files raw data_Figure 3.xlsx raw data_cellular experiments.xlsx raw data_Si Figure 4.xlsx raw data_Sl Figure 3.xlsx