MBSR

This dataset contains 147 participants, 112 patients and 35 matched healthy controls.

Dataset consists of 1 10 minute resting state scan, two 8 minute pain scans,two 5 minute MSIT scans, and 1 DTI scan.

Participant numbers sub-7000 through sub-7168 are patients.
Participant numbers sub-7500 through sub-7538 are healthy controls.

Notes:

Participants data can include up to 3 sessions.

Sessions per participant:

Not all participants completed all 3 sessions. Some completed only 2 or only 1.

Resting State scan:

Not all participants completed both 5 minute MSIT scans.

PAIN:

Not all participants completed both 8 minute pain scans.

DTI:

Not all participants completed a DTI scan.

We aimed to evaluate the efficacy of an enhanced mindfulness based stress reduction (MBSR+) versus
stress management for headache (SMH). We performed a randomized, assessor-blind, clinical trial of
98 adults with episodic migraine recruited at a single academic center comparing MBSR+ (n=50)to SMH
(n=48). MBSR+ and SMH were delivered weekly by group for 8 weeks, then bi-weekly for another 8 weeks.
The primary clinical outcome was reduction in headache days from baseline to 20 weeks. MRI outcomes
included activity of left dorsolateral prefrontal cortex (DLPFC) and cognitive task network during
cognitive challenge, resting state connectivity of right dorsal anterior insula (daINS) to DLPFC and
cognitive task network, and gray matter volume of DLPFC, daINS, and anterior midcingulate. Secondary
outcomes were headache-related disability, pain severity, response to treatment, migraine days, and MRI
whole-brain analyses. Reduction in headache days from baseline to 20 weeks was greater for
MBSR+ (7.8 [95%CI, 6.98.8] to 4.6 [95%CI, 3.75.6]) than for SMH (7.7 [95%CI 6.78.7] to 6.0 [95%CI, 4.97.0]) (P=0.04).
52% of the MBSR+ group showed a response to treatment (50% reduction in headache days) compared with 23%
in the SMH group (P=0.004). Reduction in headache-related disability was greater for MBSR+ (59.6 [95%CI, 57.961.3]
to 54.6 [95%CI, 52.956.4]) than SMH (59.6 [95%CI, 57.761.5] to 57.5 [95%CI, 55.559.4]) (P=0.02). There were no
differences in clinical outcomes at 52 weeks or MRI outcomes at 20 weeks, although changes related to cognitive
networks with MBSR+ were observed. MBSR+ is an effective treatment option for episodic migraine.

keywords: Pain, chronic pain, migraine, headache, mindfulness, meditation, longitudinal, cognitive, cognition, resting state, dti, dwi