Gene expression profiling of whole blood and peripheral neutrophils from asthma.

As part of the Taiwanese Consortium of Childhood Asthma Study (TCCAS), a new prospective sub-study was conducted to investigate the effectiveness of inhaled corticosteroids (ICS) treatment. Patients were categorized as either responders (R) or non-responders (NR), based on the improvement of their pulmonary function after ICS treatment. We analyzed the transcriptomes of asthma with ICS non-responsers and responders. Overall design: Analysis of gene expression obtained from human whole blood and peripheral neutrophils comparing ICS non-responders and responders in asthma.