Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [bulk RNA-seq]. Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [bulk RNA-seq]

Vaginal tissue Tregs acquire a inflammatory cytokine-dependent, infection-specific phenotype after local infection with HSV-2 Overall design: CD4+ FoxP3+ Tregs were isolated from the draining lymph nodes and vaginal tissue of FoxP3GFP mice +/- HSV-2 infection. These cells were then processed for 3' bulk transcriptional profiling (Takara, Illumina)