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Identification of functional variant enhancers associated with atrial fibrillation

NIAID Data Ecosystem2026-03-11 收录

心房颤动遗传机制

增强子功能分析

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133802 数据链接链接失效反馈

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资源简介：

STARR-seq analysis of human AF-associated loci in a rat inducible atrial cardiomyocyte cell line STARR-seq of AF associated loci and variants

应用场景：

创建时间：

2020-06-25

基因表达调控

增强子功能分析

DNA determines where and when genes are expressed, but the full set of sequence determinants that control gene expression is not known. Here, we measured transcriptional activity of DNA sequences that

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Multiplexed engineering and analysis of endogenous enhancer activity in single cells: Mosaic-Seq of beta-globin locus (separate infection). Homo sapiens

增强子功能分析

CRISPR转录调控

Transcriptional enhancers orchestrate cell-type specific gene expression programs critical to eukaryotic development, physiology, and disease. However, despite the large number of enhancers now identi

NIAID Data Ecosystem30

Saturating mutagenesis of the GADD45A intron 3 enhancer using STARRseq

增强子功能分析

定点饱和诱变

Assessment of individual nucleotide impact on overall GADD45A enhancer activity, dependency on p53 and/or activation through inegrated stress response (ISR). Overall design: Massively parallel reporte

NIAID Data Ecosystem10

Additional file 2 of Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

母细胞瘤靶向治疗

增强子功能分析

Additional file 2: Supplementary Table S2

Figshare2024-02-23 更新40

Characterization of sequence determinants of enhancer function using natural genetic variation [ChIP-seq]

增强子功能分析

基因组变异分析

Sequence variation in enhancers, a class of cis-regulatory elements that control cell type-specific gene transcription, contributes significantly to phenotypic variation within human populations. Enha

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Identification of functional variant enhancers associated with atrial fibrillation

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