Metabolic changes observed in AOiGHD mice.

*, Low (low-fat diet, 10% calories from fat), Moderate (standard chow diet, 17% calories from fat), High (high-fat diet, 45% calories from fat).Consistent across diets, male AOiGHD mice are more insulin sensitive, with lower circulating levels of IGF-I and insulin. As caloric intake increases adipose mass increases and liver weight decreases, where the later is associated with reduced triglyceride content (TG). Despite, improved insulin sensitivity, glucose clearance deteriorates in high-fat fed AOiGHD mice. It is hypothesized that this is due to inappropriate pancreatic insulin production, which remains to be tested. Symbols indicate increases (↑), decreases (↓), or no change (−) in AOiGHD mice, relative to GH-intact controls. nd, not determined; NMR, whole body nuclear magnetic resonance; ITT, insulin tolerance test; GTT, glucose tolerance test.