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Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation

NIAID Data Ecosystem2026-05-01 收录

神经内分泌前列腺癌

肿瘤谱系演化

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240058 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-11-24

神经内分泌前列腺癌

去势抵抗机制

Fatal neuroendocrine (NE) prostate cancer evolves from castration-resistant adenocarcinoma as a mechanism of resistance to androgen deprivation/anti androgen receptor therapies. Evidence suggests the

NIAID Data Ecosystem80

Supplementary Tables from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

神经内分泌前列腺癌

ASCL1转录因子

Supplementary Tables S1-S6

NIAID Data Ecosystem30

AmpliSeq Transcriptome Analysis of Human Prostate Cancer Cells With or Without Overt SRRM4 Expression

神经内分泌前列腺癌

转录组研究

Prostate adenocarcinoma (AdPC) cells can undergo lineage switching to neuroendocrine cells and develop into therapy-resistant neuroendocrine prostate cancer (NEPC). While genomic/epigenetic alteration

NIAID Data Ecosystem20

Increased Serine and One Carbon Pathway Metabolism by PKCl/i Deficiency Promotes Neuroendocrine Prostate Cancer [RNA-seq]

神经内分泌前列腺癌

前列腺癌代谢重编程

Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant pro

NIAID Data Ecosystem70

Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer [scATAC-seq]. Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer [scATAC-seq]

神经内分泌前列腺癌

单细胞表观遗传学

Neuroendocrine prostate cancer (NEPC) arises primarily through neuroendocrine transdifferentiation (NEtD) as an adaptive mechanism of therapeutic resistance. Models to define the functional effects of

NIAID Data Ecosystem30

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation

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