Candidate autism genes identified in 4 AGRE patients.

The Table summarizes genes identified by combined homozygosity mapping and whole exome sequencing, as described in the text. All mutations were homozygous in affected individuals and present within runs of homozygosity (ROH) ranging from 0.9–11.7 cM. All mutations were heterozygous in the parents, while unaffected siblings were either heterozygous or homozygous for the alternate allele. All candidate genes are expressed in the brain. Conservation scores were derived from the UCSC Genome Browser Vertebrate Multiz Alignment and Conservation (17 Species) track.