hCINAP expression in colorectal cancer

For analyzing the hCINAP gene in CRC, we download the recomputed TCGA gene expression datasets of COAD and READ cancer types, which is based on gencode v23 gene model, from UCSC Xena (http://xena.ucsc.edu/). The clinical data are downloaded from GDC Data Portal (https://gdc-portal.nci.nih.gov/). The expression unit is TPM (Transcript per million).For differential expression analysis, we compile a core sample set in which each sample has information available for clinical variables such as gender, age and race. The core sample set includes 367 tumor samples and 51 normal samples (Supplementary Table1). For expression analysis in different pathological stage, we only use the tumor samples and filter out the samples lack of stage information (Supplementary Table1). The dataset used for profiling gene expression across different CRC subtypes is compiled based on the results of consensus molecular subtypes(CMSs)[citation], containing 265 tumor samples (Supplementary Table1).