RNA-seq of wild-type and Cox10-/- muscle stem cells (mouse)

We report the transcriptome changes in purified mouse muscle stem cells in response to deletion of the Cox10 gene. This study identifies changes in the muscle stem cell population in response to mitochondrial dysfunction. A floxed-Cox10 allele combined with Pax7-Cre (ERT2) driver were used to induce Cox10 deletion in muscle stem cells of adult animals, via administration of tamoxifen. Two days after tamoxifen administration, muscle stem cells were purified from wild-type (control) and Cox10-/- animals.