Changes (synonymous and non-synonymous) found in <i>CLU</i> and observed in only one subject (AD case or control) in both series.

Nucleotide numbering reflects cDNA numbering with +1 corresponding to the A of the ATG translation initiation codon in the reference sequences (CLU: NM_001831.2). The initiation codon is codon 1. Genomic numbering refers to reference sequence NC_000008.9. Protein numbering refers to sequence NP_001822.2. AAO: age at onset; Fam hist: Family history; N.A.: not applicable; -: information not available. Prediction of pathogenicity was performed in silico using the PolyPhen software [27], [28], [29].