COHORT B characteristics comparing non-IBD controls with IBD cases*.

1Estimated using IBD-drug use as proxies (see text for further detail)230.2% of patients had missing data during follow-up (index date to IHD date or end of follow-up).314.2% of patients had missing data during follow-up (BMI record nearest to IHD date (+-12 months)).4Index of Multiple Deprivation (IMD) based on practice post-code. Quintile 0 is the least deprived, quintile 4 most deprived.5Charlson index [17] is a validated index of comorbidity taking into account both the number and severity of comorbidities. 0 is no comorbidities. 6 or more is a very high score indicating a high number of cormorbidities and/or severe comorbidities. For example AIDS and metastatic tumour each score 6.6Colectomy during follow-up (index date to IHD date or end of follow-up).7Non-IBD compared to IBD, comparison of binary variables by adjusted χ2 test; continuous variables by Student’s t-test; multiple category variables by χ2 test adjusted for trend*Analysis excludes cases of IHD diagnosed prior to IBD diagnosis.COHORT B characteristics comparing non-IBD controls with IBD cases*.