Analysis of the human genome and recombination cold spots (RCSs), defined as genomic DNA regions of size ≥300 kb having average recombination frequency ≤0.5 cM/Mb, for VWG chromatin signals in 100 kb windows.

Chromosome Y was excluded from the analysis. The number of signals found was adjusted to account for the influence of the signal densities of the 1-Mb regions flanking each RCS, as described in the text. The P-value (obtained from the cumulative binomial distribution) is the probability of obtaining the number of signals found or a greater value by chance.