Extended archaeal histone-based chromatin structure regulates global gene expression in Thermococcus kodakarensis

Using the model organism Thermococcus kodakarensis, we genetically alter the chromatin landscape and quantify the resultant changes in gene expression, including unanticipated and significant impacts on provirus transcription. Global transcriptome changes resultant from varying chromatin landscapes reveal the regulatory importance of higher-order histone-based chromatin architectures in regulating gene expression. Overall design: Examination of 3 variant chromatin structures on gene expression