Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

DAG-activated Pkd1 promotes triglyceride accumulation in adipocytes; Pkd1 promotes lipogenesis and suppresses mitochondrial function in adipocytes in an AMPK-dependent manner; Pkd1 suppresses expression of genes characteristic for beige adipocytes; Deletion of Pkd1 in adipocytes protects mice from diet-induced obesity, T2D and liver steatosis. Overall design: Gene expression changes in subcutaneous adipose tissue of mice after deletion of Pkd1.