Rejuvenating cognitive decline

Brain aging is characterized by a progressive loss of cellular and molecular function that are responsible for cognitive decline, and increased susceptibility to neurodegenerative disorders. Administering young mice plasma (YMP) to aged mice reverses cognitive decline and rejuvenates the brain by inhibiting neuroinflammation, although the exact mechanism is still unknown.Here, we show that a crucial involvement of microglia in the therapeutic effects of YMP.