A Central Role for RAF-MEK-ERK Signaling in the Genesis and Maintenance of Pancreatic Ductal Adenocarcinoma.

ChEBI2012-07-09 更新2026-07-21 收录

胰腺导管腺癌机制

RAF-MEK-ERK信号通路

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A Central Role for RAF-MEK-ERK Signaling in the Genesis and Maintenance of Pancreatic Ductal Adenocarcinoma.

创建时间：

2012-07-09

Setdb1 is required for formation of pancreatic ductal adenocarcinoma by inhibiting p53-mediated apoptosis in mice

胰腺导管腺癌机制

SETDB1基因

Setdb1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes tumorigenesis in various cancers. However, the functional role of Setdb1 in pancreatic ductal adenocarcinoma for

NIAID Data Ecosystem50

Endocrine-exocrine signaling in obesity-driven pancreatic ductal adenocarcinoma. Endocrine-exocrine signaling in obesity-driven pancreatic ductal adenocarcinoma

胰腺导管腺癌机制

肿瘤微环境

Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mous

NIAID Data Ecosystem30

Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice. Mus musculus

胰腺导管腺癌机制

基因表达分析

Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited

NIAID Data Ecosystem10

The tissue factor-thrombin axis drives pancreatic ductal adenocarcinoma through tumor cell-derived PAR-1

胰腺导管腺癌机制

凝血酶信号通路

RNA-Seq analysis reporting the transcriptional changes induced by treatment of mouse pancreatic ductal adenocarcinoma cell lines with thrombin for 24h Overall design: Total mRNA profiles from C57Bl/6

NIAID Data Ecosystem30

Aberrant accumulation of Kras-dependent enhancer RNAs during tumor progression renders cancer cells susceptible to PAF1 depletion due to R-loop accumulation I. Aberrant accumulation of Kras-dependent enhancer RNAs during tumor progression renders cancer cells susceptible to PAF1 depletion due to R-loop accumulation I

胰腺导管腺癌机制

成瘾治疗

Kras is the most commonly mutated oncogene in human cancer and mutant Kras is responsible for over 90% of pancreatic ductal adnocarcinoma (PDAC), the most leath cancer. Here, we identified that RNA po

NIAID Data Ecosystem20

A Central Role for RAF-MEK-ERK Signaling in the Genesis and Maintenance of Pancreatic Ductal Adenocarcinoma.

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