Intestinal iron transporters are essential for manganese absorption and excess in SLC30A10 deficiency

SLC30A10 deficiency is an inherited disease characterized by manganese excess, neurological dysfunction, liver disease, and polycythemia. It is due to loss of SLC30A10-mediated manganese excretion via the gastrointestinal tract. In this study, we investigate the role of intestinal iron transporters Dmt1 and ferroportin in absorption of manganese in Slc30a10-deficient mice.