Brain delivery and efficacy of a lysosomal enzyme using a blood-brain barrier transport vehicle
收藏NIAID Data Ecosystem2026-03-12 收录
官方服务:
资源简介:
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景:
创建时间:
2020-09-16
相关数据集
Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease
Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins acro
NIAID Data Ecosystem40
Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
Most peptides have not proved useful as neuroactive drugs because they are blocked by the blood-brain barrier and do not reach their receptors within the brain. Intraperitoneally administered L-seriny
PubMed Central1994-07-19 更新30
Brain delivery and efficacy of a lysosomal enzyme using a blood-brain barrier transport vehicle [RNA-seq]. Brain delivery and efficacy of a lysosomal enzyme using a blood-brain barrier transport vehicle [RNA-seq]
The enzyme transport vehicle (ETV:IDS) is a lysosomal enzyme fused to iduronate 2-sulfatase (ETV:IDS), the lysosomal enzyme deficient in mucopolysaccharidosis type II (MPS II). ETV:IDS treatment signi
NIAID Data Ecosystem20
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P‑Glycoprotein with Anti-HIV‑1 Activity
Combination antiretroviral therapy is the mainstay of HIV treatment, lowering plasma viral levels below detection. However, eradication of HIV is a major challenge due to cellular and anatomical viral
NIAID Data Ecosystem30
A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain
BackgroundTherapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows tra
Figshare2016-01-18 更新20



