circRNADb

It has been known that circular RNAs are widely expressed in human tissues and cells, and play important regulatory roles in physiological or pathological processes. A circRNA database, named as circRNADb, containing 32,914 human exonic circRNAs carefully selected from diversified sources was established. The detailed information of the circRNA, including genomic information, exon splicing, genome sequence, internal ribosome entry site (IRES), open reading frame (ORF) and references were provided in circRNADb. In addition, circRNAs were found to be able to encode proteins, which have not been reported in any species.

现有研究证实，环状RNA（circular RNA，circRNA）广泛表达于人体各类组织与细胞中，并在生理及病理过程中发挥重要调控作用。本研究构建了一款名为circRNADb的环状RNA数据库，该库收录了从多样化来源中精心筛选得到的32914条人类外显子环状RNA。circRNADb中提供了该类环状RNA的详细信息，包括基因组信息、外显子剪接情况、基因组序列、内部核糖体进入位点（internal ribosome entry site, IRES）、开放阅读框（open reading frame, ORF）以及相关参考文献。此外，研究发现环状RNA能够编码蛋白质，这一现象此前尚未在任何物种中被报道过。

搜集汇总

背景与挑战

背景概述

circRNADb是一个包含32,914个注释外显子环状RNA的人类环状RNA综合性数据库，适用于大规模研究。环状RNA作为稳定的非编码RNA，在基因调控中具有重要作用。