Selenosemicarbazones show marked antitumor activity. However, their mechanism of action remains unknown. We examined the medicinal chemistry of the selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3

NIAID Data Ecosystem50

Re-replication of a Centromere Induces Chromosomal Instability and Aneuploidy

染色体不稳定性

非整倍性诱导

The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performe

NIAID Data Ecosystem40

Effects of DOX and LMB on cell cycle and apoptosis of A549 cells.

抗癌药物机制

癌细胞实验

*P<0.05 in comparison to control; **P<0.01 in comparison to control. #P<0.05 in comparison to LMB alone; ##P<0.01 in comparison to LMB alone.

NIAID Data Ecosystem80

Inhibition of STAT3 by Anticancer Drug Bendamustine

抗癌药物机制

STAT3信号通路

Bendamustine (BENDA), which bears the bis(2-chloroethyl)amino moiety, is an alkylating agent that stops the growth of cancer cells by binding to DNA and interfering with its replication. However, the

NIAID Data Ecosystem40

S1 Data -

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