Structure of the human JAK1 kinase domain with compound 15
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Structure of the human JAK1 kinase domain with compound 15 Descriptor: GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 Authors: Lupardus, P.J, Brown, D. Deposit date: 2018-11-27 Release date: 2019-04-24 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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2018-11-27
