RNA-seq of Dand5 KO and WT mESC

DAND5 is an extracellular protein belonging to the family of TGF-ß/Nodal signaling antagonists Cerberus/DAN. Loss-of-function of DAND5 in mice leads to a massive increase of the ventricular heart wall's thickness caused by an increased mitotic index of the CMs at the compact myocardium. To clarify the function of DAND5 in the molecular control of cardiomyogenesis, we carried out RNA-seq of a Dand5 KO mouse embryonic stem cell line (mESC) that proved to be a valuable in vitro cardiac differentiation model.