Copper-Mediated Construction of Spirocyclic Bis-oxindoles via a Double C–H, Ar–H Coupling Process
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https://figshare.com/articles/dataset/Copper_Mediated_Construction_of_Spirocyclic_Bis_oxindoles_via_a_Double_C_H_Ar_H_Coupling_Process/2253823
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资源简介：
A double C–H,
Ar–H coupling process for the conversion
of bis-anilides into spirocyclic bis-oxindoles, enabling the concomitant
formation of two all-carbon quaternary centers at oxindole 3-positions
in a diastereoselective manner, is described. The optimum cyclization
conditions utilize stoichiometric Cu(OAc)2·H2O/KOtBu in DMF at 110 °C and have been applied
to prepare a range of structurally diverse bis-spirooxindoles in fair
to good yields (28–77%); the method has also been extended
to prepare bis-oxindoles linked by a functionalized acyclic carbon
chain.
创建时间：
2016-02-16
