First Structure–Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://figshare.com/articles/dataset/First_Structure_Activity_Relationship_Study_of_Potent_BLT2_Agonists_as_Potential_Wound-Healing_Promoters/13059442
下载链接
链接失效反馈官方服务：
资源简介：
The
first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists,
endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT),
and synthetic CAY10583 (CAY) have been recently described to accelerate
wound healing by enhanced keratinocyte migration and indirect stimulation
of fibroblast activity in diabetic rats. CAY represents a very valuable
starting point for the development of novel wound-healing promoters.
In this work, the first structure–activity relationship study
for CAY scaffold-based BLT2 agonists is presented. The newly prepared
derivatives showed promising in vitro wound-healing
activity.
创建时间：
2020-09-18
