Poor Endometrial Proliferation after Clomiphene is Associated with Altered Estrogen Action [RNA-Seq]

We report transcriptomic profiles from endometrial biopsies obtained from infertile women in the late proliferative phase who developed either optimal (=8mm) or suboptimal (<6mm) endometrial thickness following early follicular phase exposure to 100mg clomiphene citrate for 5 days. Overall design: RNA-seq analyses were conducted on whole endometrium during the late proliferative phase. In parallel, ESR1 ChIP-seq was conducted on whole endometrium during the late proliferative phase.