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NHC-Catalyzed Reaction of Enals with Hydroxy Chalcones: Diastereoselective Synthesis of Functionalized Coumarins

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Figshare2016-02-19 更新2026-04-29 收录
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https://figshare.com/articles/dataset/NHC_Catalyzed_Reaction_of_Enals_with_Hydroxy_Chalcones_Diastereoselective_Synthesis_of_Functionalized_Coumarins/2427517
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The N-heterocyclic carbene-catalyzed annulation of enals with 2′-hydroxy chalcones afford cyclopentane-fused coumarin derivatives with an excellent level of diastereocontrol. The reaction tolerates a broad range of functional groups; 25 examples are given, and a preliminary mechanistic investigation is provided.
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2016-02-19
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