Comparison between calorie-restricted and time-restricted without calorie restriction

Recently, it has been shown that fasting for a portion of each day has metabolic benefits, and promotes lifespan. These findings complicate the interpretation of rodent CR studies, which typically feed the animals only once per day; as they rapidly consume their food, such a regimen collaterally imposes fasting. Overall design: Here, we addressed if fasting alone can recapitulate the response of a CR diet, without calorie restriction at the transcriptional level.