Cryo-EM structure of 5-HT1AR-GoA in complex with TMU4142

Cryo-EM structure of 5-HT1AR-GoA in complex with TMU4142 Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 8-[3-[[(2~{S})-3-(1~{H}-indol-4-yloxy)-2-oxidanyl-propyl]amino]propyl]-8-azaspiro[4.5]decane-7,9-dione, CHOLESTEROL, ... Authors: Wang, C, Cao, C. Deposit date: 2025-06-29 Release date: 2025-11-12 Last modified: 2026-04-01 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Pathway-selective 5-HT 1A R agonist as a rapid antidepressant strategy. Cell, 188, 2025