首页/数据集/IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies. IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies

IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies. IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies

NIAID Data Ecosystem2026-03-14 收录

肿瘤靶向治疗

免疫耐受机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA937281 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2023-02-21

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

NIAID Data Ecosystem90

Discovery of N ‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1 H ‑pyrrolo[2,3‑ c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

蛋白质结构域抑制剂开发

肿瘤靶向治疗

The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under clinical development for oncol

NIAID Data Ecosystem20

A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.

肿瘤靶向治疗

ErbB抑制剂临床研究

This is a clinical study with an orally administered drug, BDTX-189 in participants with advanced solid tumors that have select mutations or alterations in human epidermal growth factor receptor 2 (HE

NIAID Data Ecosystem20

Additional file 2 of Cilengitide sensitivity is predicted by overall integrin expression in breast cancer

肿瘤靶向治疗

整合素生物标记物

Supplementary material 2.

DataCite Commons2024-12-21 更新30

Table_2_CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring.xlsx

B细胞受体序列

免疫耐受机制

IntroductionThe leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements, “stereotyped BCRs”. The B-cell re

NIAID Data Ecosystem20

IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies. IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell malignancies

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