List of significant (Bonferroni corrected p<0.05, equivalent to uncorrected p<2.44×10−5) associations in the ADNI cohort.

The most significant association of each analyte is listed in the descending order of R2SNP, which is the fraction of variation accounted for by SNP while adjusting for the effect of covariates. R2SNP is defined as follows: R2SNP is defined as follows: R2SNP = adjusted R2 of model with SNP and covariates – adjusted R2 of model with covariates.SNP: Single Nucleotide Polymorphism; ADNI: Alzheimer’s Disease Neuroimaging Initiative; Chr: Chromosome.*Gene and SNP information are based on the Genome Build 37.3.**Tested genetic model: Additive (ADD), Dominant (DOM), Hemizygosity (HEM).***Statistical model did not include APOE ε4 status due to possible collinearity.♣Gene-protein pairs in the initial and updated annotation are shown together.♣♣Association was significant only in males.