Step-Economical Synthesis of the Marine Ascidian Antibiotics Cadiolide A, B, and D
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https://figshare.com/articles/dataset/Step_Economical_Synthesis_of_the_Marine_Ascidian_Antibiotics_Cadiolide_A_B_and_D/2220004
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资源简介：
A concise, modular and efficient
synthesis of the title natural
products is reported. Prominent steps include (i) one-pot assembly
of a key β-aryl-α-benzoylbutenolide building block by
regiocontrolled “click–unclick” oxazole–ynone
Diels–Alder cycloaddition/cycloreversion and ensuing 2-alkoxyfuran
hydrolysis and (ii) a protecting group-free vinylogous Knoevenagel
condensation enabling rapid access to cadiolides A, B, and D from
a common precursor.
创建时间：
2015-01-02
