Step-Economical Synthesis of the Marine Ascidian Antibiotics Cadiolide A, B, and D
收藏NIAID Data Ecosystem2026-03-07 收录
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资源简介：
A concise, modular and efficient synthesis of the title natural products is reported. Prominent steps include (i) one-pot assembly of a key β-aryl-α-benzoylbutenolide building block by regiocontrolled “click–unclick” oxazole–ynone Diels–Alder cycloaddition/cycloreversion and ensuing 2-alkoxyfuran hydrolysis and (ii) a protecting group-free vinylogous Knoevenagel condensation enabling rapid access to cadiolides A, B, and D from a common precursor.
创建时间：
2015-01-02
