PGR-B expression in the ovary drives ovarian neoplasia and a tumorigenic transcriptome.

Constitutive PGR-B expression in PGR positive cells in the mouse drives ovarian neoplasia. To compare the differences between the PGR-B expressing ovarian neoplasia tissue and age-matched wildtype ovaries, microarray analysis was performed. It was concluded that PGR-B expression promoted a tumorigenic signature distinctly different from wildtype ovarian tissue. Wildtype and Pgrcre/+PgrBLsL/+ mice were sacrificed at 33 weeks of age. The ovaries were collected for microarray analysis.