Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels

We tested the hypothesis that increase dosage of Ube3a may exert its influence on transcriptomic organization in a sex-biased manner We performed gene expression analysis using data obtained from RNA-seq of prefrontal cortex and hypothalamus dissected from adult male and female mice with extra copies of Ube3a (Ube3a2x) and Wild-type controls