Dataset from Prospective Cohort Study of Chronic Renal Insufficiency

Insights into the cause of kidney failure have emerged from research, but less is known about
the epidemiology of less severe forms of kidney disease known both as chronic kidney disease
(CKD) or chronic renal insufficiency (CRI).

The Chronic Renal Insufficiency Cohort (CRIC) Study was established to study the consequences
of CKD with a particular focus on cardiovascular illness like myocardial infarction (heart
attack) and stroke. The CRIC Study will identify high-risk subgroups of individuals with CRI,
informing future treatment trials, and development of preventive therapies.

CRIC is an observational study that to date, over 5000 participants have been enrolled in the
CRIC cohort. The goal for CRIC 2018 which began in July 2018 is to follow participants for an
additional 5 years. To maximize the opportunities inherent in this unique scientific
resource, the CRIC Study will, in its next phase, pursue a multifaceted strategy involving:
(a) continued follow-up of the cohort and investigation of a broad array of factors
associated with the progression and consequences of CKD utilizing state-of-the-art methods in
biostatistics and bioinformatics; and (b) the use of novel remote data collection techniques
to identify trajectories of kidney function and cardiovascular risk sub-phenotypes.