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A recombinant lentiviral PDGF-driven mouse model of proneural GBM

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99361
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Informed by the genetic alterations observed in human GBM, we engineered a novel, lentiviral injection mediated, mouse model of proneural GBM. Total RNA obtained from PDGF-driven primary GBM tumors arising in the ShCdkn2a-PDGFB-T2A-CreERT2 mouse model developed in our study was analysed to determine to which transcriptomic subtype of GBM these specimens belonged.
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2018-01-24
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