New Insights into the Complex Pathophysiology of Restless Legs Syndrome from a Transcriptome Analysis of mRNAs

For this study 17 drug-free patients (13 F and 4 M, mean age 55.8 years, range 24-76; mean IRLS severity scale 21.1; mean disease duration 6.6 years) were enrolled, along with age- and sex-matched controls. RNA sequencing was used to perform this transcriptome study using the Illumina Novaseq 6000 System.