PIGA mutation and glycosylphosphatidylinositol anchor dysregulation in polyposis-associated duodenal tumorigenesis

Progression of duodenal polyposis into cancer is an important cause of morbidity and mortality in the inherited tumour syndromes Familial Adenomatous Polyposis (FAP) and MUTYH-associated Polyposis (MAP), yet this process remains poorly understood. This study aimed to identify genes that are mutated in FAP and MAP duodenal adenomas and to characterise the cellular consequences for duodenal tumorigenesis. We performed whole transcriptome sequencing were used to identify putative drivers of duodenal tumorigenesis in 70 duodenal adenomas from patients with FAP and MAP. Grant: NIH/NCI R03 CA176788-01A1 Discovering New Targets for Chemoprevention in Familial Adenomatous Polyposis Vilar-Sanchez, Eduardo / University of Texas MD Anderson Cancer Center