Oral ibuprofen is more effective than intravenous ibuprofen for closure of a patent ductus arteriosus: can pharmacokinetic modelling help us to understand why?

Dataset as used for paper in Neonatology 2022. <br> Oral ibuprofen is more effective than intravenous ibuprofen for closure of a patent ductus arteriosus: can pharmacokinetic modelling help us to understand why? <br> Authors: Cornelis Smit (Co-author), Aline G.J. Engbers (Co-author), Samira Samiee-Zafarghandy (Co-author), Tamara van Donge (Co-author), Sinno H.P Simons (Co-author), Robert B. Flint (Co-author), Marc Pfister (Co-author), Catherijne A.J. Knibbe (Corresponding author), John N. van den Anker (Co-author)<br> <br> Non-commercial use only under CC BY-NC licence. <br> <br> DATA DICTIONARY <br> # ID STUDY A STARTS WITH 2000, STUDY B AT 1 # TIME IN HOUR # AMT IN MG (50% FOR EACH ENANTIOMERE) # RATE IN MG/H FOR IV, ORAL = 0 # DV IN MG/L # MDV # CMT 1 abs s-ibu 3 abs r-ibu 2 conc s-ibu 4 conc r-ib # EVID # TAD TIME AFTER DOSE IN H # DV_TOT SUM OF R-IBU AND S-IBU DV # ENANT S-IBU = 1 R-IBU = 2 # ROA 1 = IV 2 = PO # BLOQ 1: sample was detectable, a concentration could be measured. Measured concentration is presented in DV column. # 2: sample was detectable but concentration was below the lower limit of quantification (1 µg/ml for both S- and R-ibuprofen). Measured concentration is presented in DV column. # 3: sample was non-detectable. Concentration in DV column is set at 0 µg/ml. # 0: BLOQ = 0 if was previously NA, including all DONGE samples. <br> # BWT BODY WEIGHT IN G # CWT TIME VARYING BODY WEIGHT # IPNA INTIAIL PNA IN DAYS AT START # CPNA TIME VARYING PNA IN DAYS # SEX_F GENDER, FEMALE = 1 # SGA YES = 1 below expected 10th percentile for GA # GA gestational age in weeks # FLUCO Fluconazol used max 7 days before first or 7 days after last dose = 1 # PMA POSTMENSTRUAL AGE IN WEEKS # STD STUDY A = 1 STUDY B = 2