Electrophysiological analysis of MSNs from zQ175 and WT mice.

Mean mEPSC frequency and amplitude in zQ175 wild type (WT), heterozygous (HET) and homozygous (HOM) MSNs at 2 and 7–9 months of age. Statistical comparisons were made between aged matched WT and zQ175 HET and HOM mice using either a ONE-WAY ANOVA with Tukey's post-test (ANOVA) on mean frequency and amplitude values, or by D'Agostino and Pearson omnibus normality test followed by one sample t-test, to test whether means were significantly different than WT mean values from frequency distribution analysis (D'A & P). ns = not significant, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.