The purpose of the experiment was to investigate the heterogeneity of islet cell response, especially beta-cells to hyperglycemia induced by severe insulin resistance in mice. Overall design: Mice w

NIAID Data Ecosystem50

Assessing the effect of leptin central administration on plasma proteins in insulin deficient mice.

糖尿病分子机制

激素替代疗法

Leptin monotherapy (i.e. without the use of administered insulin and/or any other molecule) corrects ID-induced metabolic aberrancies and promotes survival of insulin deficient rodents. These results

NIAID Data Ecosystem40

Chemerin-induced down-regulation of placenta-derived exo-somal miR-140-3p and miR-574-3p promotes umbilical vein endothelial cells proliferation, migration, and tube formation in gestational diabetes mellitus. Chemerin-induced down-regulation of placenta-derived exo-somal miR-140-3p and miR-574-3p promotes umbilical vein endothelial cells proliferation, migration, and tube formation in gestational diabetes mellitus

糖尿病分子机制

血管内皮功能

Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes and fetoplacental endothelial dysfunction; however, the underlying mechanisms are still unknown. This study aimed to investigate th

NIAID Data Ecosystem60

Proteomics and RNA-seq of TGP-200c and LNA-200c in MIN6 cells

RNA调控机制

糖尿病分子机制

Global Proteomics: The effect of LNA-200c (100 nM) on the proteome was studied. Amongst 3,016 proteins detected, 29 were significantly affected (10 down-regulated and 19 up-regulated. Interestingly,

NIAID Data Ecosystem40

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet B-cell Endoplasmic Reticulum Stress and Proliferation

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