HeLa-A549-293T_SyntheticLethal

Combined synthetic-lethal network for all three cell lines. Circles indicate TSG, squares DTs. Node colors indicate single gene knockout fitness effect, red: positive fitness effect, blue: negative fitness effect. Black edge around node indicates that the protein product of the gene is the target of an FDA approved drug. Color of edge indicates the cell line in which the interaction was identified, blue: HeLa, red: A549, green: 293T. Black edges were identified in multiple cell lines.