BrainProt v3.0: An Integrative and Simplified Omics-Based Knowledge-Base About the Human Brain and Its Associated Diseases

The advancements in neuroscience research and omics technologies
generate extensive data for brain-related diseases and disorders that
are scattered across various manuscript repositories and databases,
potentially hindering global initiatives to advance neuroscience research.
This study introduces BrainProt v3.0 (https://www.brainprot.org/), an omics-driven knowledge-base of human brain and associated diseases.
BrainProt version 3.0 navigates the Human Brain Disease Atlas (HBDA)
and integrates the Brain Disease Marker Curator (BDMC) and Brain Disease
Drug Finder (BDDF). It features 20,202 disease-associated genes, 136,557
chemical target interactions, and 2,145 clinical trial details. Additionally,
the Brain Disease Transcriptome Map (BDTM) and Brain Disease Proteome
Map (BDPM) collate multiomics data from the most significant brain
diseases, displaying an expression profile across 52 datasets and
1,868 samples. This platform also facilitates the exploration of biological
cross-talk and correlations between transcriptomics and proteomics
data to identify critical disease-associated markers. In conclusion,
BrainProt is designed to advance the Human Brain Proteome Project
(HBPP) by expanding the integration of diseases and datasets, thereby
elucidating the complexities of brain diseases and enhancing the research
on the interplay between brain tumors and neurodegenerative disorders.