Clinical Associations with the Hyper-Hemolysis Phenotype in Sickle Cell Anemia.

Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; α thalassemia refers to co-existing heterozygosity or homozygosity for α3.7 (genotypes αα/-α3.7 and -α3.7/-α3.7 combined); ACS, acute chest syndrome as a prevalence; GFR, glomerular filtration rate in mL/min.; PH, pulmonary hypertension defined by triscuspid regurgitant jet velocity (TRJV) ≥2.5 m/s; severe PH, severe pulmonary hypertension defined by TRJV ≥3.0 m/s; Elevated BNP, N-terminal pro brain naturetic peptide ≥160 pg/mL and ND, not determined. The total number of subjects in each study group is listed at the top of the table along with the actual number of subjects with available data for each parameter.
*Mann Whitney nonparametric test.
†Reported as the number of subjects with detectable haptoglobin levels (greater than 6 mg/dL).
‡Adjusted for hydroxyurea exposure.
§Emergency room visits only for the evaluation of severe episodes of acute sickle cell related pain.