With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin
(SM = severe malaria, all entities, SP = severe prostration, SA = severe anaemia, CM = cerebral malaria, SRD = severe respiratory distress). In the top row, the odds ratio (OR) is shown for the associ
The initial study and data description are published in: Band G et al . (2013). Imputation-based meta-analysis of severe malaria in three African populations . PLoS Genet. 9:e1003509. This data rele
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of