dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes

Welcome to the official documentation overview for dbEM, a specialized database developed to maintain and analyze genomic information for epigenetic proteins that serve as potential cancer targets. This resource compiles extensive data on mutations, expression levels, and gene essentiality to aid in the discovery of epigenetic protein-based cancer therapeutics.

Database URL: https://webs.iiitd.edu.in/raghava/dbem/index.php

Citation

Singh Nanda, J., Kumar, R., & Raghava, G. P. S. (2016). dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Scientific Reports, 6, 19340. https://doi.org/10.1038/srep19340

About the Database

Epigenetics is the study of heritable changes in cellular phenotype that do not involve alterations to the underlying DNA sequence. Abnormal expression or genomic alterations in chromatin regulators are known to drive oncogenesis. dbEM provides a centralized platform to analyze the epigenetic landscape in cancer, identifying potential targets for drug development.

The database integrates information from several primary resources:

Genomic Variations: Data retrieved from COSMIC, CCLE, and the 1000 Genomes Project.

Gene Essentiality: Sourced from the COLT-cancer database.

Post-Translational Modifications (PTM): Compiled from dbPTM.