Global Burden of Disease Study 2021 (GBD 2021) Sickle Cell Disease Birth Incidence, Prevalence, and Mortality 2000-2021

Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this dataset provides a global assessment of sickle cell disease (SCD) birth incidence, prevalence and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. It includes estimates for three distinct genotype-specific SCD models: homozygous SCD and severe sickle cell/beta thalassaemia (SS and Sβ°), sickle cell-hemoglobin C disease (SC), and “mild” sickle cell/beta thalassaemia (Sβ+). The three model estimates were summed into estimates for “total SCD mortality.” The latter can be compared against the estimates provided for the GBD cause "Sickle cell disorders," both of which are also included in the dataset. Refer to the related publication for information on modeling methods and analysis.